Product Overview
5-Amino-1MQ (5-Amino-1-methylquinoline) is a small, membrane-permeable synthetic molecule designed specifically to function as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT)[cite: 4]. NNMT is a cytosolic enzyme highly active in adipose tissue and skeletal muscle, making this compound an integral reference standard for studying metabolic expenditure, cellular energy orchestration, and cellular aging mechanisms[cite: 4].
By selectively suppressing NNMT activity, 5-Amino-1MQ acts as a key molecular tool to explore intracellular nicotinamide adenine dinucleotide (NAD+) recycling dynamics and sirtuin 1 (SIRT1) expression. This targeted biochemical pathway allows researchers to observe shifts in energy homeostasis and lipolytic profiles within isolated cellular assays[cite: 4].
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 5-Amino-1-methylquinolin-1-ium iodide |
| Molecular Formula | C₁₀H₁₁IN₂ |
| Molecular Mass | 286.11 g/mol |
| Purity Standard | ≥ 98.0% (HPLC & Mass Spectrometry Verified)[cite: 4] |
| Physical Format | Sterile, off-white to pale yellow, crystalline powder |
Laboratory Handling & Storage Guidelines
- Solubility: Highly soluble in dimethyl sulfoxide (DMSO) and standard laboratory-grade organic solvents. Ensure completely homogenous dissolution before adding to aqueous cellular assay mediums[cite: 4].
- Long-Term Storage: Store the raw lyophilized powder desiccated at -20°C[cite: 4]. Protect meticulously from moisture, atmospheric humidity, and strong direct light[cite: 4].
- Solution Stability: Once dissolved in solvent, store working aliquots at -80°C to minimize degradation over extended experimental schedules. Avoid repeated freeze-thaw cycles[cite: 4].
⚠️ Regulatory Compliance & Mandatory Disclaimer
IMPORTANT NOTICE: This product is synthesized and distributed exclusively as a pure research chemical for laboratory evaluation, academic investigation, and in vitro experimental models[cite: 4]. IT IS STRICTLY NOT FOR HUMAN CONSUMPTION, DIAGNOSTIC, THERAPEUTIC, OR COSMETIC APPLICATIONS.[cite: 4] All purchasing entities must represent certified academic or scientific research professionals[cite: 4].
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