Mots-C

Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a synthetic 16-amino acid peptide encoded within the mitochondrial genome rather than the nuclear DNA. As a unique mitochondrial-derived peptide (MDP), it functions as a critical systemic signaling molecule that translocates to the nucleus under metabolic duress, serving as a primary reference standard for investigating cellular homeostasis, insulin sensitivity kinetics, and longevity biology.

Preclinical and cell-line models indicate that MOTS-c regulates metabolic equilibrium primarily via the activation of the 5′-adenosine monophosphate-activated protein kinase (AMPK) pathway. It serves as an essential scientific tool to monitor glucose clearance, cellular stress responses, and mitochondrial-nuclear communication matrices during in vitro evaluations.

Technical Specifications

Laboratory Handling & Storage Guidelines

• Reconstitution: Reconstitute using sterile bacteriostatic water or standard laboratory-grade saline solution. Gently swirl the vial in a smooth circular motion; avoid aggressive mechanical vortexing to prevent structural shearing of the peptide bond configuration.
• Long-Term Storage: Store the raw lyophilized powder desiccated at -20°C to -80°C. Protect meticulously from moisture contamination, atmospheric humidity variations, and direct solar light exposure.
• Short-Term Stability: Post-reconstitution, the matrix must be stored under stable refrigeration at 2°C to 8°C and utilized within 14 days to preserve maximum biochemical tissue integrity.

⚠️ Regulatory Compliance & Mandatory Disclaimer

IMPORTANT NOTICE: This product is synthesized and distributed exclusively as a pure research chemical for laboratory evaluation, academic investigation, and in vitro experimental models. IT IS STRICTLY NOT FOR HUMAN CONSUMPTION, DIAGNOSTIC, THERAPEUTIC, OR COSMETIC APPLICATIONS. All purchasing entities must represent certified academic or scientific research professionals.