Product Overview
SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide engineered as a structural elongation of the popular hexapeptide Argireline. Operating as a competitive mimic of the endogenous SNAP-25 protein, this compound is widely evaluated in laboratory models for its capacity to disrupt the assembly of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) complex.
In preclinical cell cultures and biomolecular frameworks, SNAP-8 is utilized as a reference standard to observe the inhibition of neurotransmitter exocytosis, specifically modulating the calcium-dependent release of acetylcholine at simulated synaptic junctions. Its high sequence precision is strictly verified using advanced analytical separation testing to guarantee reproducible biochemical alignment during in vitro evaluation.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Profile | Synthetic SNARE Complex Competitor (Octapeptide) |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular Mass | 1075.16 g/mol |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Purity Standard | ≥ 98.0% (HPLC & Mass Spectrometry Verified) |
| Physical Format | Sterile, white, lyophilized crystalline powder |
Laboratory Handling & Storage Guidelines
- Reconstitution: Reconstitute using sterile bacteriostatic water or standard analytical saline solutions. Gently swirl the vial in a smooth circular motion; avoid high-shear vortexing or harsh mechanical mixing to protect the structural integrity of the elongated peptide chain.
- Long-Term Storage: Store the raw lyophilized powder desiccated at -20°C to -80°C. Protect meticulously from ambient moisture, atmospheric humidity variations, and direct light exposure.
- Short-Term Stability: Post-reconstitution, the matrix solution must be stored under stable refrigeration at 2°C to 8°C and utilized within 14 days to preserve maximum biochemical sequence integrity.
⚠️ Regulatory Compliance & Mandatory Disclaimer
IMPORTANT NOTICE: This product is synthesized and distributed exclusively as a pure research chemical for laboratory evaluation, academic investigation, and in vitro experimental models. IT IS STRICTLY NOT FOR HUMAN CONSUMPTION, DIAGNOSTIC, THERAPEUTIC, OR COSMETIC APPLICATIONS. All purchasing entities must represent certified academic or scientific research professionals.
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