Product Overview
ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide derived from the non-erythropoietic structure of Erythropoietin (EPO). Engineered specifically to isolate tissue-protective pathways, this compound operates as a highly selective agonist of the Innate Repair Receptor (IRR)—a heterodimer composed of erythropoietin receptor and beta common receptor subunits—without stimulating erythropoiesis or altering red blood cell mass variables.
Within preclinical biomolecular frameworks and cell cultures, ARA-290 serves as an essential reference standard to investigate neuroprotective mechanisms, peripheral nerve architecture stability, and targeted anti-inflammatory signaling cascades. It actively modulates the down-regulation of pro-inflammatory cytokines and suppresses tissue damage pathways under induced metabolic or mechanical stress models.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Profile | Non-Erythropoietic Tissue-Protective Peptide Fragment |
| Molecular Formula | C₅₁H₈₄N₁₆O₂₁ |
| Molecular Mass | 1257.3 g/mol |
| Sequence | Glp-Leu-Ser-Gln-Glu-Met-Glu-Glu-Val-Gly-Gln (Glp: Pyroglutamic acid) |
| Purity Standard | ≥ 98.0% (HPLC & Mass Spectrometry Verified) |
| Physical Format | Sterile, white, lyophilized crystalline powder |
Laboratory Handling & Storage Guidelines
- Reconstitution: Reconstitute using sterile bacteriostatic water or standard analytical saline solutions. Gently swirl the vial in a smooth circular motion; avoid high-shear mechanical vortexing to protect the baseline structural configuration of the 11-amino acid chain.
- Long-Term Storage: Store the raw lyophilized powder desiccated at -20°C to -80°C. Protect meticulously from moisture contamination, ambient atmospheric humidity variations, and direct light exposure.
- Short-Term Stability: Post-reconstitution, the matrix solution must be stored under stable refrigeration at 2°C to 8°C and utilized within 14 days to preserve maximum biochemical sequence integrity.
⚠️ Regulatory Compliance & Mandatory Disclaimer
IMPORTANT NOTICE: This product is synthesized and distributed exclusively as a pure research chemical for laboratory evaluation, academic investigation, and in vitro experimental models. IT IS STRICTLY NOT FOR HUMAN CONSUMPTION, DIAGNOSTIC, THERAPEUTIC, OR COSMETIC APPLICATIONS. All purchasing entities must represent certified academic or scientific research professionals.
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